2021年

  • Selective capture and non-invasive release of cells using a thermoresponsive polymer brush with affinity peptides. Kenichi Nagase, Masaki Shimura, Ruka Shimane, Kengo Hanaya, Sota Yamada, Aya Mizutani Akimoto, Takeshi Sugai, Hideko Kanazawa. Biomaterials Science,9,3,663-674,(2021)
    Front coverに選ばれました
  • 温度応答性高分子を利用した抗体医薬品分離技術の開発. 長瀬健一, 金澤秀子, B&I バイオサイエンスとインダストリー,79(1),38-39,(2021)

ページ先頭へ

2020年

  • Temperature-responsive chromatography for bioseparations: A review. Kenichi Nagase, Hideko Kanazawa.Analytica Chimica Acta,1138,191-212,(2020)
    Front coverに選ばれました
  • Thermoresponsive Cationic Block Copolymer Brushes for Temperature-Modulated Stem Cell Separation. Kenichi Nagase, Ayumu Ota, Tadashi Hirotani, Sota Yamada, Aya Mizutani Akimoto, Hideko Kanazawa.Macromolecular Rapid Communications,2000308,(2020)
    Front coverに選ばれました
  • Design of two complementary copolymers that work as a glue for cell-laden collagen gels. Taihei Nishimoto, Ko Matsukawa, Kenichi Nagase, Hideko Kanazawa, Aya Mizutani Akimoto, Ryo Yoshida.Chemical Communications, 56, 10545-10548,(2020)
  • 刺激応答性高分子を用いたバイオセパレーション. 長瀬健一, 金澤秀子, 高分子, 69(9), 472-473, (2020)
  • Antibody drug separation using thermoresponsive anionic polymer brush modified beads with optimised electrostatic and hydrophobic interactions. Kenichi Nagase, Saki Ishii, Koji Ikeda, Sota Yamada, Daiju Ichikawa, Aya Akimoto, Yutaka Hattori, Hideko Kanazawa.Scientific Reports 10, 11896, (2020)
  • Simultaneous analysis of multiple oligonucleotides by temperature-responsive chromatography using a poly(N-isopropylacrylamide)-based stationary phase. Yutaro Maekawa, Kaichi Yamazaki, Miwa Ihara, Kenichi Nagase, Hideko Kanazawa.Analytical and Bioanalytical Chemistry, 412, 5341-5351, (2020)
  • Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography. Yutaro Maekawa, Naoya Okamoto, Yuji Okada, Kenichi Nagase, Hideko KanazawaScientific Reports10(1), 8828, (2020)
  • Mixed polymer brush as a functional ligand of silica beads for temperature-modulated hydrophobic and electrostatic interactions, Kenichi Nagase, Sakiko Kitazawa, Sota Yamada, Aya Mizutani Akimoto, Hideko Kanazawa. Analytica Chimica Acta, 1095, 1-13, (2020)
    Front coverに選ばれました
  • Thermoresponsive anionic copolymer brush-grafted surfaces for cell separation. Kenichi Nagase, Naho Uchikawa, Tadashi Hirotani, Aya Mizutani Akimoto, Hideko Kanazawa.Colloids and Surfaces B: Biointerfaces, 185, 110565, (2020)

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2019年

  • Phenotypic traits of mesenchymal stem cell sheets fabricated by temperature-responsive cell culture plate: structural characteristics of MSC sheets. Mitsuyoshi Nakao, Kyungsook Kim, Kenichi Nagase, David W. Grainger, Hideko Kanazawa, Teruo Okano. Stem Cell Research & Therapy, 10(1), 353, (2019)
  • Temperature-responsive mixed-mode column containing temperature-responsive polymer-modified beads and anionic polymer-modified beads. Kenichi Nagase, Maria Watanabe, Fumihiko Zen, Hideko Kanazawa. Analytica Chimica Acta, 1079, 220-229, (2019)
  • Crosslinked Poly(N-Isopropylacrylamide)-Based Microfibers as Cell Manipulation Materials with Prompt Cell Detachment. Tomomi Konishi, Aya Mizutani Akimoto, Taihei Nishimoto, Yuki Tokura, Mizuki Tenjimbayashi, Kenta Homma, Ko Matsukawa, Taisei Kaku, Yuki Hiruta, Kenichi Nagase, Hideko Kanazawa, Seimei Shiratori. Macromolecular Rapid Communications, 40(23), 1900464, (2019)
  • 効果的な心筋細胞シート移植のためのVEGF徐放ファイバーマットの設計. 長瀬健一, 金澤秀子. Drug Delivery System, 34(3), 173-178, (2019)
  • Characteristic differences of cell sheets composed of mesenchymal stem cells with different tissue origins. Mitsuyoshi Nakao, Daimu Inanaga, Kenichi Nagase, Hideko Kanazawa. Regenerative Therapy, 11, 34-40 (2019)
  • Temperature-modulated cell-separation column using temperature-responsive cationic copolymer hydrogel-modified silica beads. Kenichi Nagase, Daimu Inanaga, Daiju Ichikawa, Aya Mizutani Akimoto, Yutaka Hattori, Hideko Kanazawa. Colloids and Surfaces B: Biointerfaces, 178, 253-262 (2019).
    Front coverに選ばれました。
  • 効果的ながん治療を目指したCD44ターゲティングナノキャリア. 山之内 翔, 金澤秀子. Drug Delivery System, 34(1), 38-45, (2019)
  • LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells. Minami Maekawa-Matsuura, Kei Fujieda, Yutaro Maekawa, Tomohiro Nishimura, Kenichi Nagase, Hideko Kanazawa. ACS Omega , 4(4), 6443-6451 (2019).
  • Adsorption-Desorption Control of Fibronectin in Real Time at the Liquid/Polymer Interface on a Quartz Crystal Microbalance by Thermoresponsivity. Jiatu Li, Taisei Kaku, Yuki Tokura, Ko Matsukawa, Kenta Homma, Taihei Nishimoto, Yuki Hiruta , Aya Mizutani Akimoto, Kenichi Nagase, Hideko Kanazawa, and Seimei Shiratori.Biomacromolecules, 20(4), 1748-1755.
  • Liposomes with temperature-responsive reversible surface properties Ryo Nemoto, Kei Fujieda, Yuki Hiruta, Mafumi Hishida, Eri Ayano, Yoshie Maitani, Kenichi Nagase, Hideko Kanazawa. Colloids and Surfaces B: Biointerfaces, 176, 309-316 (2019).
  • Effect of Polymer Phase Transition Behavior on Temperature-Responsive Polymer-Modified Liposomes for siRNA Transfection Kenichi Nagase, Momoko Hasegawa, Eri Ayano, Yoshie Maitani and Hideko Kanazawa. International Journal of Molecular Sciences, 20(2), 430 (2019).

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2018年

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2017年

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2016年

  • Thermoresponsive Anionic Block Copolymer Brushes with Strongly Anionic Bottom Segment for Effective Interactions with Biomolecules. Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa and Teruo Okano. RSC Advances, 6, 93169-93179 (2016).
  • Design of tetra-arm PEG-crosslinked thermoresponsive hydrogel for 3D cell culture. Aya Mizutani Akimoto, Erika Hasuike, Hiroto Tada, Kenichi Nagase, Teruo Okano, Hideko Kanazawa, Ryo Yoshida. Analytical Sciences, 32, 1203 (2016).
  • Transcutaneous drug delivery by liposomes using fractional laser technology. Takahiro Fujimoto, Jian Wang, Kazuki Baba, Yuka Oki, Yuki Hiruta, Masayuki Ito, Shinobu Ito, Hideko Kanazawa. Lasers in Surgery & Medicine, (2016)
  • Approaching over 10 000-fold sensitivity increase in chiral capillary electrophoresis: Cation-selective exhaustive injection and sweeping cyclodextrin-modified micellar electrokinetic chromatography. Mikuma T., Iwata Y.T., Miyaguchi H., Kuwayama K., Tsujikawa K., Kanamori T., Kanazawa H., Inoue H. Electrophoresis, 37(22), 2970-2976 (2016).
  • 超高速液体クロマトグラフィーを用いた向精神薬の複数同時迅速分析. 芳川満輝、内田亮、黒木巽、三熊敏靖、蛭田勇樹、永田佳子、金澤秀子 Bunseki Kagaku, 65(4), 173-179 (2016)
  • Temperature-responsive molecular recognition chromatography using phenylalanine and tryptophan derived polymer modified silica beads. Hiruta Y, Kanazashi R, Ayano E, Okano T, Kanazawa H. Analyst, 141(3), 910-917 (2016).
    Analyst誌のBack coverに選ばれました。
  • Protein separations via thermally responsive ionic block copolymer brush layers. Nagase K, Kobayashi J, Kikuchi, A, Akiyama Y, Kanazawa H, Okano T. RSC Advances, 6, 26254-26263 (2016).

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2015年

  • Thermoresponsive Hydrophobic Copolymer Brushes Modified Porous Monolithic Silica for High-Resolution Bioseparation. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. RSC Advances, 5, 66155-66167 (2015).
  • Effects of Terminal Group and Chain Length on Temperature-Responsive Chromatography Utilizing Poly(N-isopropylacrylamide) Synthesized via RAFT Polymerization. Hiruta Y, Nagumo Y, Miki A, Okano T, Kanazawa H. RSC Advances, 5, 73217-73224 (2015).
  • Temperature-responsive Solid-phase Extraction Column for Biological Sample Pretreatment. Akimaru M, Okubo K, Hiruta Y, Kanazawa H. Anal. Sci., 31(9),881-886 (2015)
  • Design of Environmentally Responsive Fluorescent Polymer Probes for Cellular Imaging. Yamada A, Hiruta Y, Wang J, Ayano E, Kanazawa H. Biomacromolecules, 16, 2356-2362 (2015).
  • The effects of anionic electrolytes and human serum albumin　on the LCST of poly(N-isopropylacrylamide)-based temperature-responsive copolymers. Hiruta Y, Nagumo Y, Suzuki Y, Funatsu T, Ishikawa Y, Kanazawa H. Colloids and Surfaces B: Biointerfaces, 132, 299-304 (2015).
  • Measurement of the dynamic behavior of thin poly(N-isopropylacrylamide) hydrogels and their phase transition temperatures measured using reflectometric interference spectroscopy. Okada F, Akiyama Y, Kobayashi J, Ninomiya H, Kanazawa H, Yamato M, Okano T. J. Nanopart. Res., 17, 148 (2015).
  • The mechanism of melanocytes-specific cytotoxicity induced by phenol compound having a pro-oxidant effect, relating to the appearance of leukoderma. Nagata T, Ito S, Itoga K, Kanazawa H, Masaki H. Biomed. Res. Int., Article ID 479798, 12 pages (2015).
  • Simultaneous Analysis of Oral Antidiabetic Drug by LC-MS/MS. Kai S, Ishikawa K, Ito H, Ogawa T, Yamashita H, Nagata Y, Kanazawa H. Chromatography, 36, 19-24 (2015).
  • pH/temperature-responsive fluorescence polymer probe with pH-controlled cellular uptake. Hiruta Y, Funatsu T, Matsuura M, Wang J, Ayano E, Kanazawa H. Sensors and Actuators B, 207, 724-731 (2015).
  • 降圧配合錠の製剤学的性質が成分溶出性に与える影響. 永田佳子, 阿南ゆりえ, 金澤秀子. BUNSEKI KAGAKI (分析化学), 64(11), 835-844 (2015).

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2014年

  • Liquid Chromatography-Mass Spectrometric Analysis of Dehydroepiandrosterone and Related Steroids Utilizing a Temperature-Responsive Stationary Phase. Ayano E, Suzuki Y, Nishio T, Nagata Y, Kanazawa H, Nagase K, Okano T. Chromatograpy, 35, 131-138 (2014).
  • 超高速LCを用いる複合型抗酸化サプリメント成分の迅速定量分析. 平出園絵, 星野由依, 重田まりあ, 蔭山大輔, 金澤秀子, 永田佳子. BUNSEKI KAGAKI (分析化学), 63(8), 679-685 (2014)
  • Monolithic Silica Rods Grafted with Thermoresponsive Anionic Polymer Brushes for High-Speed Separation of Basic Biomolecules and Peptides. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Biomacromolecules, 15(4), 1204-1215 (2014).
  • Temperature-Responsive Fluorescence Polymer Probes with Accurate Thermally Controlled Cellular Uptakes. Hiruta Y, Shimamura M, Matsuura M, Maekawa Y, Funatsu T, Suzuki Y, Ayano E, Okano T, Kanazawa H. ACS Macro Lett., 3, 281-285 (2014).
  • Thermoresponsive Copolymer Brushes Possessing Quaternary Amine Groups for Strong Anion-Exchange Chromatographic Matrices. Nagase K, Geven M, Kimura S, Kobayashi J, Kikuchi A, Akiyama Y, Grijpma D. W, Kanazawa H, Okano T. Biomacromolecules, 15, 1031-1043 (2014).
  • High temperature heat source generation with quasi-continuous wave semiconductor lasers at low power levels of 6W for medical use. Fujimoto T, Imai Y, Tei K, Fujioka T, Ito S, Kanazawa H, Yamaguchi S. J. Biomed. Opt., 19(10), 101502 (2014).
  • 分子認識部位を導入した機能性高分子修飾充填剤による温度応答性クロマトグラフィー. 坂田和貴, 大久保廣平, 蛭田勇樹, 綾野絵理, 金澤秀子. 高分子論文集(Kobunshi Ronbunshu), 71(7), 293-301 (2014).
  • Temperature-responsive smart packing materials utilizing multi-functional polymers. Ayano E, Kanazawa H*. Anal. Sci., 30, 167-173 (2014).

    • ページ先頭へ


2013年

  • 陽イオン交換樹脂を用いる放射性セシウムの除去. 森田裕子, 水村亮介, 橘 義貴, 金澤秀子. 分析化学, 62(6), 541-545 (2013).
  • フォトダイオードアレイ検出器を備えた超高速LCによる降圧配合錠の確認試験. 宮野弘之, 金澤秀子, 永田佳子. 分析化学, 62(8), 743-750 (2013).
  • 超高速HPLCを用いる経口糖尿病薬の複数同時迅速分析と配合錠への応用. 柄本圭弘, 石川 謙, 伊藤 一, 平出園絵, 永田佳子, 金澤秀子. 分析化学, 62(8), 725-730 (2013).
  • Thermally modulated cationic copolymer brush on monolithic silica rods for high-speed separation of acidic biomolecules. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. ACS Appl. Mater. Interfaces. 5(4), 1442-52 (2013).
  • Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata). Miyabe-Nishiwaki T, Masui K, Kaneko A, Nishiwaki K, Nishio T, Kanazawa H. J Vet Pharmacol Ther, 36(2), 169-73 (2013).

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2012年

  • 超高速液体クロマトグラフィーを用いるロキソプロフェンナトリウム錠溶出試験. 三浦 唯, 永田佳子, 金澤秀子. BUNSEKI KAGAKU, 61(8), 713-718 (2012).
  • Poly (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake. Ayano E, Karaki M, Ishihara T, Kanazawa H, Okano T. Colloids and Surfaces B: Biointerfaces, 99, 67-73 (2012).
  • Effect of Polymer Containing a Naphthyl-Alanine Derivative on the Separation Selectivity for Aromatic Compounds in Temperature-Responsive Chromatography, Nishio T, Kanazashi R, Nojima A, Kanazawa H, Okano T. J. Chromatogr. A, 1228, 148-154 (2012).
  • High Stability of Thermoresponsive Polymer-Brush-Grafted Silica Beads as Chromatography Matrices. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. ACS Applied Materials & Interfaces, 4(4), 1998-2008 (2012).
  • Thermoresponsive Poly(N-isopropylacrylamide)-Based Block Copolymer Coating for Optimizing Cell Sheet Fabrication, Nakayama M, Yamada N, Kumashiro Y, Kanazawa H, Yamato M, Okano T. Macromol Biosci. 12(6), 751-60 (2012).
  • pH-Induced Phase Transition Control of Thermoresponsive Nano-micelles Possessing Outermost Surface Sulfonamide Moieties. Nakayama M, Kawahara Y, Akimoto J, Kanazawa H, Okano T. Colloids and Surfaces B: Biointerfaces, 99, 12-19 (2012).
  • Induction of different reactive oxygen species in the skin during various laser therapies and their inhibition by fullerene. Fujimoto T, Ito S, Ito M, Kanazawa H, Yamaguchi S. Lasers in Surgery & Medicine, 44(8), 685-94 (2012).

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2011年

  • Effect of reaction solvent on the preparation of thermoresponsive stationary phase through a surface initiated atom transfer radical polymerization. Nagase K, Mizutani Akimoto A, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. J Chromatography A, 1218, 8617-8628 (2011).
  • Thermoresponsive Polymer Brush on Monolithic-Silica-Rod for the High-Speed Separation of Bioactive Compounds. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Langmuir, 27(17), 10830-9 (2011).
  • Estimation of the postmortem duration of mouse tissue by electron spin resonance spectroscopy, Ito S, Mori T, Kanazawa H, Sawaguchi T. Journal of Toxicology, 2011, Article ID:973172 (2011).
  • Reaction monitoring of tocopherols with active nitrogen oxides by ultra high-speed liquid chromatography. Nagata Y, Nishio T, Kanazawa H. J. Pharm. Biomed. Anal., 55, 241-246 (2011).
  • Thermo-responsive protein adsorbing materials for purifying pharmaceutical　protein on exposed charging surface. Nagase K, Yuk S F, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. J. Mater. Chem.21(8), 2590-2593 (2011).
  • Thermally-modulated on/off-adsorption materials for pharmaceutical protein purification. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Biomaterials, 32, 619-627 (2011).
  • Separation of phosphorylated peptides utilizing dual pH-and temperature-responsive chromatography. Nishio T, Ayano E, Suzuki Y, Kanazawa H, Okano T. J. Chromatogr. A, 1218(15), 2079-84 (2011).
  • LC-MS/MSによる畜水産物中のメトリブジンおよび代謝物の分析. Kai H, Akaboshi T, Waki M, Fuzimaki T, Kanazawa H. 食品衛生学雑誌, 52(1), 28-33(2011).

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2010年

  • Preparation of thermo-responsive polymer brushes on hydrophilic polymeric beads by surface-initiated atom transfer radical polymerization for a highly resolutive separation of peptides. Mizutani A, Nagase K, Kikuchi A, Kanazawa H, Akiyama Y, Kobayashi J, Annaka M, Okano T. J. Chromatogr. A, 1217, 5978-5985 (2010).
  • Thermoresponsive polymer brush surfaces with hydrophobic groups for all-aqueous chromatography. Nagase K, Kumazaki M, Kanazawa H, Kobayashi J, Kikuchi A, Akiyama Y, Annaka M, Okano T. ACS Appl Mater Interfaces, 2(4), 1247-53 (2010).
  • Hydration of Poly(N-isopropylacrylamide) Brushes on Micro-silica Beads Measured by a Fluorescent Probe. Hattori Y, Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Chemical Physics Letters, 491, 193-198 (2010).
  • Effective separation of peptides using highly dense thermo-responsive polymer brush-grafted porous polystyrene beads. Mizutani A, Nagase K, Kikuchi A, Kanazawa H, Akiyama Y, Kobayashi J, Annaka M, Okano T. J. Chromatogr. B, 878, 2191-2198 (2010).
  • Thermo-responsive polymer brush-grafted porous polystyrene beads for all-aqueous chromatography. Mizutani A, Nagase K, Kikuchi A, Kanazawa H, Akiyama Y, Kobayashi J, Annaka M, Okano T. J. Chromatogr. A, 1217, 522-529 (2010).
  • 西尾 忠，金澤秀子. 多機能性ポリマーを用いる環境低負荷型クロマトグラフィーシステムの開発. BUNSEKI KAGAKU, 59, 163-173 (2010).
  • Preparation of Thermoresponsive Anionic Copolymer Brush Surfaces for Separating Basic Biomolecules. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Annaka M, Okano T. Biomacromolecules, 11(1), 215-223 (2010).
  • Hypnotic effects and pharmacokinetics of a single slow bolus dose of propofol in Japanese macaques (Macaca fsucata fsucata). Miyabe-Nishiwaki T, Masui K, Kaneko A, Nishiwaki K, Shimbo E, Kanazawa H. Vet Anaesth Analg, 37, 501-510 (2010).

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2009年

  • Dual Temperature- and pH-Responsive Fluorescence Molecular Probe for Cellular Imaging utilizing a PNIPAAm- Fluorescein Copolymer. Kobayashi H, Nishikawa M, Sakamoto C, Nishio T, Kanazawa H, Okano T.Anal. Sci. 25, 1043-1047 (2009).
  • Aqueous chromatographic system for the quantification of propofol in biological fluids using a temperature-responsive polymer modified stationary phase. Nishio T, Suzuki R, Tsukada Y, Kanazawa H, Okano T, Miyabe-Nishiwaki T. J. Chromatogr. A, 1216, 7427-7432 (2009).
  • Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness. Ishihara T, Kubota T, Choia T, Takahashi M, Ayano E, Kanazawa H, Higaki M. Int J Pharm. 375(1-2), 148-154 (2009).
  • Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides. Ishihara T, Goto M, Kodera K, Kanazawa H, Murakami Y, Mizushima Y, Higaki M. Drug Delivery, 16(3), 153-159 (2009).
  • Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles.Ishihara T, Goto M, Kanazawa H, Higaki M, Mizushima Y. J. Pharm. Sci. 98(7), 2357-2363 (2009).
  • Development of Novel Thermally Responsible Separation Systems using Functional Polymers. Kanazawa H. Chromatography, 30(1), 1-9 (2009).

ページ先頭へ


2008年

  • Influence of graft interface polarity on hydration/dehydration of grafted　thermoresponsive polymer brushes and steroid separation using all-aqueous　chromatography. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Annaka M. Kanazawa H, Okano T. Langmuir, 24(19), 10981-10987 (2008).
  • Preparation of Thermoresponsive Cationic Copolymer Brush Surfaces and Application of the Surface to Separation of Biomolecules. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Biomacromolecules, 9(4), 1340-1347 (2008).
  • Aqueous Chromatographic system for Separation of Biomolecules using Thermoresponsive Polymer Modified Stationary Phase. Kanazawa H, Nishikawa M, Mizutani A, Sakamoto C, Morita-Murase Y, Nagata Y, Kikuchi A, Okano T. J. Chromatogr. A, 1191, 157-161 (2008).
  • Preparation of Thermoresponsive Polymer Brush Surfaces and Their Interaction with Cells. Mizutani A, Kikuchi A, Yamato M, Kanazawa H, Okano T. Biomaterials, 29, 2073-2081 (2008).
  • Effects of graft densities and chain lengths on separation of bioactive compounds by nanolayered thermoresponsive polymer brush surfaces. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Langmuir, 24(2), 511-517 (2008).

ページ先頭へ


2007年

  • 畜水産物中動物用医薬品スクリーニング分析法としての高速液体クロマトグラフィー/タンデム質量分析法の検討.　甲斐茂美，赤星猛，藤巻照久，伊藤伸一，金澤秀子. 分析化学, 56(12), 1105-1113 (2007).
  • Interfacial property modulation of thermoresponsive polymer brush surfaces and their interaction with biomolecules. Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Langmuir, 23(18), 9409-15 (2007).
  • Deferential effects of the ascorbyl and tocopheryl derivative on the methamphetamine-induced toxic behavior and toxicity. Ito S, Mori T, Kanazawa H, Sawaguchi T. Toxicology, 240(1-2), 96-110 (2007).
  • Analysis of Melatonin using pH- and Temperature-responsive Aqueous Chromatographic System. Ayano E, Suzuki Y, Kanezawa M, Sakamoto C, Morita-Murase Y, Nagata Y, Kanazawa H*, Kikuchi A, Okano T. J. Chromatogr. A, 1156, 213-219 (2007).
  • Metabolism of bisphenol A in the rat syncytiotrophoblast cell line, TR-TBT 18d-1. Ikeda Y, Nakashima E, Kanazawa H, Tamura H*. J Health Sci, 53, 146-150 (2007).
  • Thermally Responsible Chromatographic Materials using Functional Polymers. Kanazawa H. J. Sep. Sci., 30, 1648-1656 (2007). WILEY-VCH
  • A developed determination of midazolam and 1'-hydroxymidazolam in plasma by liquid chromatography-mass spectrometry: Application to human pharmacokinetic study for measurement of CYP3A activity. Shimizu M, Uno T, Tamura H, Kanazawa H, Murakami I, Tateishi T. J. Chromatogr. B Analyt Technol Biomed Life Sci., 847(2), 275-81 (2007).
  • 環境応答性高分子を用いた新規分離システム. 金澤将史, 南部杏子, 鈴木祐輔, 西川真由美, 金澤秀子*. 分析化学(Bunseki Kagaku), 56(6), 397-407 (2007).

ページ先頭へ


2006年

  • Study of a Capillary LC System using Temperature-Responsive Polymer-Modified Packing Materials. Kanezawa M, Ayano E, Kanazawa H, Akiyama Y, Okano T. CHROMATOGRAPHY, 27, 111-115 (2006).
  • Pharmacokinetics of fentanyl after single intravenous injection and constant rate infusion in dogs. Sano T, Nishimura R, Kanazawa H, Igarashi E, Nagata Y, Mochizuki M, Sasaki N. Anaesth Analg. 33(4), 266-73 (2006).
  • Increased F2-Isoprostane Levels in the Rat Brain and Plasma Caused by Oxidative Stress and Aging, and Inhibitory Effect of Vitamin E. Nishio T, Miyadera R, Sakai R, Abe K, Kanazawa H, Fukui K, Urano S. J Clin Biochem Nutr, 38, 161-166 (2006).
  • Study of temperature-responsibility on the surfaces of a thermo-responsive polymer modified stationary phase. Ayano E, Okada Y, Sakamoto C, Kanazawa H*, Kikuchi A, Okano T. J. Chromatogr. A, 1119/1-2, 51-57 (2006).
  • Aqueous chromatography system using pH- and temperature-responsive stationary phase with ion-exchange groups. Ayano E, Nambu K, Sakamoto C, Kanazawa H*, Kikuchi A, Okano T. J. Chromatogr. A, 1119/1-2, 58-65 (2006).
  • Separation of Nucleotides with an Aqueous Mobile Phase Using pH- and Temperature-Responsive Polymer Modified Packing Materials. Ayano E, Sakamoto C, Kanazawa H*, Kikuchi A, Okano T. Anal. Sci., 22, 539-543 (2006).
  • Simultaneous determination of catechins and procyanidins in bottled tea drinks by LC/MS. Murakami I, Nakamura T, Ishibashi Y, Shibuya R, Ayano E, Morita-Murase Y, Nagata Y, Kanazawa H*. CHROMATOGRAPHY, 27(1), 19-25 (2006).
  • Temperature-responsive stationary phase utilizing a polymer of proline derivative for hydrophobic interaction chromatography using an aqueous mobile phase. Kanazawa H*, Ayano E, Sakamoto C, Yoda R, Kikuchi A, Okano T. J. Chromatogr. A, 1106, 152-158 (2006).
  • Aqueous chromatography system using temperature-responsive polymer modified stationary phase. Ayano E, Kanazawa H. J. Sep. Sci.，29, 738-749 (2006).

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2005年

  • LC/MS/MSによる畜産物中のベンズイミダゾール系寄生虫駆虫剤の分析. 甲斐茂美, 赤星 猛, 岸美智子, 金澤秀子, 小林静子. 分析化学, 54(9), 775-782 (2005).
  • Analysis of herbicides in water using temperature-responsive chromatography and an aqueous mobile phase. Ayano E, Okada Y, Sakamoto C, Kanazawa H, Okano T, Ando M, Nishimura T. J. Chrmatogr. A, 1069(2), 281-285 (2005).
  • Electron-Transfer Mechanism in Radical-Scavenging Reactions by a Vitamin E Model in a Protic Medium. Nakanishi I, Kawashima T, Ohkubo K, Kanazawa H, Inami K, Mochizuki M, Fukuhara K, Okuda H, Ozawa T, Itoh S, Fukuzumi S, Ikota N. Org. Biomol. Chem., 3(4), 626-629 (2005).
  • 機能性高分子を用いた温度応答性クロマトグラフィーの開発．綾野絵理，金澤秀子. 分析化学(Bunseki Kagaku)，54(7), 593-603 (2005).

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2004年

  • Water-Accelerated Radical-Scavenging Reaction of (+)-Catechin in an Aprotic Medium. Nakanishi I, Kawashima T, Fuikuhara K, Kanazawa H, Okuda H, Fukuzumi S, Ozawa T, Ikota N. ITE Lett. Batt. New Tech. Med., 5(6), 585-588 (2004).
  • Temperature-responsive polymers for liquid phase separations. Kanazawa H. Analytical and Bioanalytical Chemistry, 378, 46-48 (2004).
  • Temperature- and pH-responsive aminopropylsilica ion-exchange columns grafted with copolymers of N-isopropylacrylamide. Sakamoto C, Okada Y, Kanazawa H*, Ayano E, Nishimura T, Ando M, Kikuchi A, Okano T. J. Chrmatogr. A, 1030, 247-253 (2004).
  • Determination of midazolam and its metabolite as a probe for CYP3A4 phenotype by liquid chromatography-mass spectrometry. Kanazawa H*, Okada A, Igarashi E, Higaki M, Miyabe T, Sano T, Nishimura R. J. Chrmatogr. A, 1031, 213-218（2004).
  • Determination and quantitation of sulfonylurea and urea herbicudes in water samples using liquid chromatography with electrospray　ionization mass spectrometric detection. Ayano E, Kanazawa H, Ando M, Nishimura T. Analytica Chimica Acta, 507, 215-222 (2004).
  • Analysis of the Products of Reaction between - or -Tocopherol and Nitrogen Oxides Using HPLC with UV-VIS and APCI-MS Detection. Nagata Y, Matsumoto Y, Kanazawa H*. J. Chrmatogr. A, 1036, 177-182 (2004).

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2003年

  • Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype. Kanazawa H, Okada A, Higaki M, Yokota H, Mashige F, Nakahara K. J. Pharm. Biomed. Anal., 30(6), 195-202 (2003).
  • 温度応答性クロマトグラフィーによるカテキン類の分離. 坂本千賀子，岡田裕司，金澤秀子*，菊池明彦，岡野光夫. 分析化学，52(10), 903-906 (2003).
  • 緑茶飲料中カテキン類のCYP3A4による代謝系への阻害効果の解析. 中村拓己，浅田絵美，永田佳子，金澤秀子. 分析化学，52(9), 769-773 (2003).

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2002年

  • Temperature-Responsive Chromatography Using Poly(N-Isopropylacrylamide) Hydrogel-Modified Silica. Kanazawa H, Ayano E, Sunamoto T, Matsushima Y, Kikuchi A, Okano T. Anal.Sci., 18(1), 45-48 (2002).
  • Determination of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry. Kanazawa H, Okada A, Matsushima Y, Mashige F, Okubo S, Yokota H, Nakahara K. J. Chrmatogr. A, 949, 1-9, (2002).
  • Stereospecific Analysis of Loxoprofen in Plasma by Chiral Column Liquid Chromatography with A Circular Dichroism -Based Detector. Kanazawa H, Tsubayashi A, Nagata Y, Matsushima Y, Mori C, Kizu J, Higaki M. J. Chrmatogr. A, 948, 303-308 (2002).

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2001年

  • Environmental responsive chromatography. Ayano E, Kanazawa H, Kikuchi A, Okano T. Anal.Sci., 17, 873-874 (2001).
  • Temperature-responsive chromatography. -Effects of temperature gradient-. Kanazawa H, Ayano E, Chiba K, Kikuchi A, Okano T. Anal. Sci., 17, 875-876 (2001).
  • Determination of Omeprazole and its Metabolites in Human Plasma as a Probe For CYP2C19 Phenotype. Okada A, Kanazawa H, Mashige F, Okubo S, Yokota S. Anal. Sci., 17, 871-872 (2001).

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2000年

  • Temperature-Responsive Chromatographic Separation of Amino Acid Phenylthiohydantoins using Aqueous Media as the Mobile Phase. Kanazawa H, Sunamoto T, Matsushima Y, Kikuchi A, Okano T. Anal. Chem., 72, 5961-5966 (2000).
  • Preparation of Packing Materials for Temperature-Responsive Chromatography. Modification of Silica Surface with Poly(N-isopropylacrylamide). Yamamoto K, Kanazawa H, Matsushima Y, Takai N, Kikuchi A, Okano T. Chromaotgraphy, 21, 209-215 (2000).
  • Determination of Tocopherol And Tocopherylquinone in Rat Tissues And Plasma By High-Performance Liquid Chromatography with Electrochemical Detection. Kanazawa H, Miyata C, Nagata Y, Urano S, Matsushima Y. Chem. Pharm. Bull., 48(10), 1462-1466 (2000).
  • Reaction of 2,2,5,7,8-Pentamethyl-6-chromanol, an α Tocopherol Analogue, with NO in the Presence of Oxygen. Nagata Y, Nishio T, Matsumoto S, Kanazawa H, Mochizuki M, Matsushima Y. Bioorg. Med. Chem. Lett.(Bioorganic & Medicinal Chemistry Letters), 10, 2709-2712 (2000).
  • Spectrophotometric analysis of lorazepam in plasma by chiral chromatography-circular dichroism (CD) based detector. Kanazawa H, Kunito Y, Matsushima Y, Okubo S, Mashige F. J. Chrmatogr. A, 871, 181-188 (2000).
  • Determination of theophylline and its metabolites in biological samples by liquid chromatography-mass spectrometry. Kanazawa H, Atsumi R, Matsushima Y, Kizu J. J. Chrmatogr. A, 870, 87-96 (2000).
  • Temperature-Responsive Chromatographic Separation of Bisphenol A with Water as a Sole Mobile Phase. Yamamoto K, Kanazawa H, Matsushima Y, Oikawa K, Kikuchi A, Okano T. Environmental Sciences, 7(1), 047-056 (2000).
  • D-Serine Concentration in Blood Serum of Liver Transplanted Patients. Okubo S, Mashige F, Hashimoto Y, Nakahara K, Kanazawa H, Matsushima Y, Fukushima T, Huang Y, Imai K. Chromaotgraphy, 21, 43-47 (2000).
  • Enantiometric determination of L- and D-lactatic acid in human cerebrospinal fluid by chiral ligand exchange high-performance liquid chromatography. Okubo S, Mashige F, Omori M, Hashimoto Y, Nakahara K, Kanazawa H, Matsushima Y. Biomed. Chromatogr., 14, 474-477 (2000).
  • カチオン性温度応答表面による酸性生理活性物質の分離. 小林 純, 中山幸子, 菊池明彦, 金澤秀子, 松島美一, 酒井清孝, 岡野光夫. 医工学治療, 12(1), 670-676 (2000).
  • HPLCによるテオフィリンとその代謝物の同時分析．金澤秀子, 木津純子, 松島美一. 薬学雑誌, 120(10), 1051-1060 (2000).

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